Identifying important genes linked to diseases using single-cell data
New approaches for leveraging single-cell data to identify disease-critical genes and gene sets
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11055359
This study is looking at how certain genes might play a role in complex diseases by combining different types of genetic data, and it aims to find new ways to help patients through better treatments and gene editing.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11055359 on ClinicalTrials.gov |
What this research studies
This research aims to uncover critical genes and gene sets that contribute to complex diseases by integrating large-scale single-cell genomic and epigenomic data with genome-wide association studies (GWAS). By developing new computational methods, the project will analyze data from various sources, such as RNA sequencing and ATAC sequencing, to better understand the genetic factors involved in human diseases. Patients may benefit from insights gained through this research, which could lead to the identification of new drug targets and inform gene editing strategies. The research is conducted at prestigious institutions, ensuring a high level of expertise and innovation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with complex genetic diseases or those at risk due to their genetic makeup.
Not a fit: Patients with purely environmental diseases or those without a genetic component may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drug targets and improved gene therapies for complex diseases.
How similar studies have performed: Other research has shown success in using similar approaches to integrate genomic data for understanding complex diseases, indicating a promising avenue for this study.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEY, KUSHAL KUMAR — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: DEY, KUSHAL KUMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.