Identifying important genes linked to diseases using single-cell data
Official title: New approaches for leveraging single-cell data to identify disease-critical genes and gene sets
Funded at Sloan-Kettering Inst Can Research · NIH-11055359 · Data updated 2026-11-12
This study is looking at how certain genes might play a role in complex diseases by combining different types of genetic data, and it aims to find new ways to help patients through better treatments and gene editing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 10, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HG012203-05 |
| Project ID | NIH-11055359 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with complex genetic diseases or those at risk due to their genetic makeup.
✕Less likely to help
Patients with purely environmental diseases or those without a genetic component may not receive benefits from this research.
What this research studies
This research aims to uncover critical genes and gene sets that contribute to complex diseases by integrating large-scale single-cell genomic and epigenomic data with genome-wide association studies (GWAS). By developing new computational methods, the project will analyze data from various sources, such as RNA sequencing and ATAC sequencing, to better understand the genetic factors involved in human diseases. Patients may benefit from insights gained through this research, which could lead to the identification of new drug targets and inform gene editing strategies. The research is conducted at prestigious institutions, ensuring a high level of expertise and innovation.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drug targets and improved gene therapies for complex diseases.
How similar studies have gone: Other research has shown success in using similar approaches to integrate genomic data for understanding complex diseases, indicating a promising avenue for this study.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Dey, Kushal Kumar — Sloan-Kettering Inst Can Research
- Study coordinator: Dey, Kushal Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.