Identifying immune signatures in bacterial sepsis using single-cell genomic profiling
Single-cell genomic profiling to identify immune signatures of bacterial sepsis in humans
This study is looking at how examining individual immune cells in the blood of patients with bacterial sepsis can help find unique signs of the condition, making it easier to detect and treat sepsis early on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11021078 on NIH RePORTER |
What this research studies
This research investigates how single-cell genomic profiling can help identify unique immune signatures in patients suffering from bacterial sepsis. By analyzing the gene expression of individual immune cells, the study aims to improve early detection and understanding of sepsis, which is often difficult due to its varied symptoms. The approach involves collecting blood samples from patients and using advanced techniques to profile immune cells, potentially leading to the discovery of new biomarkers for diagnosis and treatment. This could ultimately enhance patient outcomes by enabling timely and targeted interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals presenting with symptoms of bacterial sepsis, particularly those with vague or non-specific signs.
Not a fit: Patients with non-bacterial infections or those not experiencing sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment options for patients with bacterial sepsis.
How similar studies have performed: Previous research has shown promise in using single-cell profiling to identify immune signatures in related conditions, suggesting potential for success in this novel application.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Goldberg, Marcia B — Massachusetts General Hospital
- Study coordinator: Goldberg, Marcia B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.