Identifying immune markers in head and neck cancer for better immunotherapy responses
DNA-based Immune Phenotyping in HNSCC for Biomarkers of Response to Immunotherapy
This study is looking at ways to better understand how certain immune cells behave in patients with head and neck cancer, so we can find new markers that help predict how well they might respond to immunotherapy treatments, ultimately aiming to create more personalized care for each patient.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11003723 on NIH RePORTER |
What this research studies
This research focuses on head and neck squamous cell carcinomas (HNSCC), which are aggressive tumors that often evade the immune system. The study aims to develop new biomarkers that can help predict how well patients will respond to immunotherapy treatments. By using advanced techniques to analyze DNA methylation patterns in immune cells, researchers hope to uncover critical insights into the immune environment surrounding these tumors. This could lead to more personalized treatment strategies for patients with HNSCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinoma who are considering or currently undergoing immunotherapy.
Not a fit: Patients with other types of cancers or those not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of patients who are likely to benefit from immunotherapy, enhancing treatment outcomes.
How similar studies have performed: Previous research has shown promise in using biomarkers to predict responses to immunotherapy in various cancers, indicating that this approach could be effective for HNSCC as well.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Kelsey, Karl Timothy — Brown University
- Study coordinator: Kelsey, Karl Timothy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.