Identifying imaging markers of nerve damage in multiple sclerosis
Toward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple Sclerosis
This study is looking at how we can see nerve damage in people with multiple sclerosis using special imaging techniques, which could help us track how the disease changes over time and how well new treatments are working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064891 on NIH RePORTER |
What this research studies
This research investigates how axonal damage, which is a key factor in the progression of multiple sclerosis (MS), can be detected using advanced imaging techniques. By employing high-gradient diffusion MRI, the study aims to visualize changes in axonal structure over time, particularly in relation to demyelination. The goal is to validate these imaging findings against tissue samples to better understand how nerve damage evolves in MS patients. This could lead to improved monitoring of disease progression and the effectiveness of new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are experiencing varying degrees of disability.
Not a fit: Patients with other neurological conditions or those without a diagnosis of multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a reliable imaging method to track nerve damage in MS, potentially leading to better treatment strategies.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques to assess axonal damage in MS, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Huang, Susie Yi — Massachusetts General Hospital
- Study coordinator: Huang, Susie Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.