Identifying how noncoding genetic variations affect health and disease
The Duke FUNCTION Center: Pioneering the comprehensive identification of combinatorial noncoding causes of disease
This study is looking at how certain genetic changes that don’t directly code for proteins can affect how our genes work, which is important for understanding health and diseases, and it’s designed for anyone interested in how genetics can impact their well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10909395 on NIH RePORTER |
What this research studies
This research focuses on understanding how noncoding genetic variations influence gene regulatory elements, which play a crucial role in health and disease. By utilizing advanced technologies, including CRISPR, the project aims to measure the combinatorial effects of these regulatory elements in their natural genomic contexts. This approach seeks to unravel the complex interactions between regulatory elements and their contributions to various diseases, ultimately improving our understanding of genetic associations with health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders or those interested in understanding the genetic basis of their health conditions.
Not a fit: Patients with purely environmental or lifestyle-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of diseases, potentially informing more effective treatments and preventive strategies.
How similar studies have performed: Other research has shown promise in using advanced genomic technologies to understand genetic variations, indicating that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Reddy, Timothy E — Duke University
- Study coordinator: Reddy, Timothy E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.