Identifying how mitochondrial changes affect colorectal cancer growth
A systems-metabolism approach to identify mitochondria-dependent vulnerabilities in colorectal cancer
This study is looking at how the energy-producing parts of cells, called mitochondria, work in colorectal cancer and how changes in them might help cancer cells grow better in different parts of the body, like the gut and liver, which could lead to new ways to treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10903896 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial function in colorectal cancer (CRC) by examining how changes in mitochondrial structure and metabolism influence tumor growth. It focuses on the impact of oncogenic RAS signaling on mitochondrial dynamics and how these changes affect the cancer cells' ability to thrive in different metabolic environments, such as the gut and liver. By utilizing a systems biology approach, the research aims to uncover metabolic adaptations that allow CRC cells to survive and proliferate in these unique settings, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with mutations in the KRAS oncogene.
Not a fit: Patients with non-colorectal cancers or those without KRAS mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that specifically disrupt the metabolic adaptations of colorectal cancer cells, improving treatment outcomes for patients.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Kashatus, David Francis — University of Virginia
- Study coordinator: Kashatus, David Francis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.