Identifying how infections cause oxidative damage to proteins linked to cancer.
Chemoproteomic discovery and functional characterization of infection-induced oxidation sites
This study is looking at how infections can cause changes in our cells that might lead to cancer, focusing on certain proteins that react to stress from germs, and it aims to find new ways to understand and possibly treat this connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11007217 on NIH RePORTER |
What this research studies
This research investigates the role of oxidative stress caused by microbial infections in the development of cancer. It focuses on understanding how specific proteins in human cells are modified during infection, particularly those containing redox-sensitive cysteines. By using advanced chemical proteomic techniques, the study aims to identify and quantify these modifications, which are often overlooked by traditional methods. This could lead to new insights into how infections contribute to cancer and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of microbial infections that may be associated with cancer development.
Not a fit: Patients who do not have any history of microbial infections or related cancer risks may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer linked to microbial infections.
How similar studies have performed: Other research has shown promising results in understanding the role of oxidative stress in cancer, but this specific approach using chemical proteomics is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Hatzios, Stavroula — Yale University
- Study coordinator: Hatzios, Stavroula
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.