Identifying how infections cause oxidative damage to proteins linked to cancer.
Official title: Chemoproteomic discovery and functional characterization of infection-induced oxidation sites
Funded at Yale University · NIH-11007217 · Data updated 2026-11-12
This study is looking at how infections can cause changes in our cells that might lead to cancer, focusing on certain proteins that react to stress from germs, and it aims to find new ways to understand and possibly treat this connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 5, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $660,337 |
| NIH project number | 5R01AI182086-02 |
| Project ID | NIH-11007217 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of microbial infections that may be associated with cancer development.
✕Less likely to help
Patients who do not have any history of microbial infections or related cancer risks may not benefit from this research.
What this research studies
This research investigates the role of oxidative stress caused by microbial infections in the development of cancer. It focuses on understanding how specific proteins in human cells are modified during infection, particularly those containing redox-sensitive cysteines. By using advanced chemical proteomic techniques, the study aims to identify and quantify these modifications, which are often overlooked by traditional methods. This could lead to new insights into how infections contribute to cancer and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer linked to microbial infections.
How similar studies have gone: Other research has shown promising results in understanding the role of oxidative stress in cancer, but this specific approach using chemical proteomics is relatively novel.
Where this research is happening
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Yale University
New Haven, United States Active
Researchers
- Principal investigator: Hatzios, Stavroula — Yale University
- Study coordinator: Hatzios, Stavroula
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.