Identifying how cancer drugs interact with tissues in the body
Official title: A platform to identify in vivo targets of covalent cancer drugs in 3D tissues
Funded at Scripps Research Institute, the · NIH-10931412 · Data updated 2026-11-12
This study is working on a new way to see how cancer drugs attach to their targets in the body, which could lead to better treatments that work well and have fewer side effects for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $435,254 |
| NIH project number | 5R33CA281918-02 |
| Project ID | NIH-10931412 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancers that are currently treated with covalent drugs or those who may benefit from new targeted therapies.
✕Less likely to help
Patients with non-cancerous conditions or those not receiving treatment with covalent drugs may not benefit from this research.
What this research studies
This research focuses on developing a new platform to visualize how covalent cancer drugs bind to their targets within living tissues. By using advanced imaging techniques and chemoproteomics, the study aims to provide detailed insights into both the intended effects of these drugs and any potential side effects. This approach will help researchers understand the interactions of drugs with cancer-related proteins, especially those that have been difficult to target in the past. Patients may benefit from improved cancer treatments that are more effective and have fewer side effects.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer cancer treatments for patients.
How similar studies have gone: Previous research has shown promise in using similar imaging techniques to study drug interactions, indicating potential for success in this novel approach.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Ye, Li — Scripps Research Institute, the
- Study coordinator: Ye, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.