Identifying high-risk patients with Barrett's esophagus using biomarkers
Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagus
['FUNDING_R37'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11212161
This study is looking at ways to find out which patients with Barrett's esophagus are more likely to develop cancer, by testing tissue samples to identify helpful markers, so that those at higher risk can get the right care early on.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11212161 on ClinicalTrials.gov |
What this research studies
This research focuses on Barrett's esophagus, a condition that can lead to esophageal adenocarcinoma, by developing a panel of biomarkers to identify patients at high risk of cancer progression. The study will analyze tissue samples from patients with Barrett's esophagus to determine which biomarkers are most effective for risk stratification. By comparing results from different patient cohorts, the researchers aim to create a reliable assay that can help in early detection and treatment of those at risk. This approach could significantly improve patient outcomes by allowing for targeted interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Barrett's esophagus, particularly those with non-dysplastic Barrett's esophagus or low-grade dysplasia.
Not a fit: Patients without Barrett's esophagus or those with advanced esophageal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of patients at risk for esophageal cancer.
How similar studies have performed: Previous research has shown promise in using biomarkers for cancer risk stratification, making this approach both relevant and potentially impactful.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STACHLER, MATTHEW D — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: STACHLER, MATTHEW D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: advanced disease, Barrett Syndrome