Identifying high-risk patients with Barrett's esophagus using biomarkers
Official title: Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagus
Funded at University of California, San Francisco · NIH-11212161 · Data updated 2026-11-12
This study is looking at ways to find out which patients with Barrett's esophagus are more likely to develop cancer, by testing tissue samples to identify helpful markers, so that those at higher risk can get the right care early on.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 28, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $69,402 |
| NIH project number | 3R37CA269649-03S1 |
| Project ID | NIH-11212161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Barrett's esophagus, particularly those with non-dysplastic Barrett's esophagus or low-grade dysplasia.
✕Less likely to help
Patients without Barrett's esophagus or those with advanced esophageal cancer may not benefit from this research.
What this research studies
This research focuses on Barrett's esophagus, a condition that can lead to esophageal adenocarcinoma, by developing a panel of biomarkers to identify patients at high risk of cancer progression. The study will analyze tissue samples from patients with Barrett's esophagus to determine which biomarkers are most effective for risk stratification. By comparing results from different patient cohorts, the researchers aim to create a reliable assay that can help in early detection and treatment of those at risk. This approach could significantly improve patient outcomes by allowing for targeted interventions.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of patients at risk for esophageal cancer.
How similar studies have gone: Previous research has shown promise in using biomarkers for cancer risk stratification, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Stachler, Matthew D — University of California, San Francisco
- Study coordinator: Stachler, Matthew D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.