Identifying high-risk children with sepsis to improve treatment outcomes
Official title: Phenotype prediction and therapeutic targets in high-risk pediatric sepsis-associated MODS
Funded at Lurie Children's Hospital of Chicago · NIH-11001542 · Data updated 2026-11-12
This study is looking at how sepsis impacts kids in intensive care, so we can find out which children are most at risk and create better, faster treatments just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $365,676 |
| NIH project number | 5R01HD113695-02 |
| Project ID | NIH-11001542 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-21 who are admitted to a PICU with sepsis or sepsis-associated complications.
✕Less likely to help
Patients who are not diagnosed with sepsis or are outside the age range of 0-21 may not benefit from this research.
What this research studies
This research focuses on understanding the different ways sepsis affects children, particularly those in pediatric intensive care units (PICUs). By identifying specific high-risk groups and their unique characteristics, the research aims to develop targeted treatments that can be implemented quickly and effectively. The approach involves analyzing clinical data to uncover patterns that can help predict which children are at greater risk of severe outcomes. This could lead to more personalized and timely interventions for affected children.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and treatment effectiveness for children suffering from sepsis-associated multiple organ dysfunction syndrome.
How similar studies have gone: Previous research has shown promise in identifying specific phenotypes in critically ill children, suggesting that this approach could lead to meaningful advancements in treatment.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Sanchez-Pinto, Lazaro Nelson — Lurie Children's Hospital of Chicago
- Study coordinator: Sanchez-Pinto, Lazaro Nelson
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.