Identifying heart function markers in patients with aortic stenosis
Multi-omic markers of cardiac function and structure within the pressure overloaded heart
This study is looking at how different biological markers can help doctors understand heart function in patients with aortic stenosis, especially older adults, so they can spot those who might need heart valve surgery sooner to avoid serious damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10895552 on NIH RePORTER |
What this research studies
This research investigates how multi-omic markers can help assess cardiac function and structure in patients suffering from aortic stenosis, a serious heart condition. By analyzing various biological data, the study aims to identify patients at risk of irreversible heart damage who may benefit from earlier aortic valve replacement surgery. The approach focuses on developing precise measures to guide clinical decisions, potentially improving patient outcomes. The research is particularly relevant for elderly patients, who often experience delays in treatment due to misattributed symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly patients diagnosed with severe aortic stenosis who are at risk of irreversible cardiac damage.
Not a fit: Patients with mild aortic stenosis or those who are not experiencing significant symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier interventions for patients with aortic stenosis, improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in using omics-based approaches to improve patient outcomes in various cardiac conditions, suggesting potential success for this novel application.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Elmariah, Sammy — University of California, San Francisco
- Study coordinator: Elmariah, Sammy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.