Identifying harmful T cells in a type of arthritis that affects the spine and eyes
Identification of Pathogenic T cells in Axial Spondyloarthritis
This study is looking at how certain immune cells, called CD8 T cells, behave in people with axial spondyloarthritis, especially when it causes eye inflammation, to help us understand the condition better and find new ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10878955 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, particularly CD8 T cells, in axial spondyloarthritis, a condition that can cause inflammation in both the joints and the eyes. By examining the differences between immune cells in the eye and those in the blood, the study aims to uncover the mechanisms behind ocular inflammation associated with this disease. The research utilizes advanced techniques like single-cell RNA sequencing to analyze these immune cells in detail. The goal is to enhance our understanding of how this condition affects patients and to identify potential targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with axial spondyloarthritis, particularly those experiencing ocular symptoms like anterior uveitis.
Not a fit: Patients without axial spondyloarthritis or those whose symptoms are not related to ocular inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from axial spondyloarthritis and its associated eye complications.
How similar studies have performed: Other research has shown promise in understanding immune mechanisms in related conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Paley, Michael Alexander — Washington University
- Study coordinator: Paley, Michael Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.