Identifying harmful immune cells in axial spondyloarthritis
Identification of Pathogenic T cells in Axial Spondyloarthritis
['FUNDING_CAREER'] · WASHINGTON UNIVERSITY · NIH-11292090
This study is looking at how certain immune cells affect eye inflammation in people with axial spondyloarthritis, which could help us understand how this condition impacts both the eyes and joints.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11292090 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific immune cells in axial spondyloarthritis, particularly focusing on how these cells contribute to ocular inflammation. By examining the immune responses in the eye and comparing them to those in the joints, the study aims to uncover the mechanisms behind this systemic disease. The approach involves advanced techniques like single-cell RNA sequencing to identify and characterize pathogenic T cells in patients with HLA-B27+ anterior uveitis, a common complication of the condition. This could lead to a better understanding of how these immune cells function and their impact on both eye and joint health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with axial spondyloarthritis, particularly those experiencing anterior uveitis.
Not a fit: Patients without axial spondyloarthritis or those not experiencing ocular symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from axial spondyloarthritis and its associated ocular complications.
How similar studies have performed: Other research has shown promise in understanding immune mechanisms in rheumatologic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PALEY, MICHAEL ALEXANDER — WASHINGTON UNIVERSITY
- Study coordinator: PALEY, MICHAEL ALEXANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bechterew Disease