Identifying gut bacteria that predict responses to ovarian cancer treatment
Multi-omic Predictive Markers for Ovarian Cancer Therapy Response and Outcomes
This study is looking at how the bacteria in your gut might affect how well certain cancer treatments work for women with ovarian cancer, with the hope of finding ways to tailor treatments to help each patient more effectively.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project ID | NIH-10678828 on NIH RePORTER |
What this research studies
This research investigates how gut bacteria may influence the effectiveness of platinum-based therapies in women with epithelial ovarian cancer (EOC). By analyzing the relationship between gut microbiota and treatment outcomes, the study aims to identify biomarkers that can predict which patients will respond well or poorly to therapy. The approach involves collecting and analyzing biological samples from patients to understand the interactions between gut bacteria, the tumor microenvironment, and immune responses. This could lead to more personalized treatment strategies for ovarian cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with epithelial ovarian cancer who are about to undergo platinum-based chemotherapy.
Not a fit: Patients with non-epithelial ovarian cancers or those who are not receiving platinum-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for women with ovarian cancer by identifying which patients are likely to benefit from specific therapies.
How similar studies have performed: While the role of gut bacteria in cancer treatment response is a growing area of interest, this specific approach to ovarian cancer therapy response is novel and has not been extensively tested in human studies.
Where this research is happening
Pittsburgh, UNITED STATES
- Magee-Women's Res Inst and Foundation — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Modugno, Francesmary — Magee-Women's Res Inst and Foundation
- Study coordinator: Modugno, Francesmary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.