Identifying gut bacteria linked to drug-resistant infections after organ transplants
Official title: Microbial biomarkers of intestinal MDR colonization after solid organ transplantation
Funded at Columbia University Health Sciences · NIH-11050763 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect the chances of getting tough infections after a solid organ transplant, with the hope of finding ways to better manage antibiotics and improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 2, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $841,520 |
| NIH project number | 1R01AI183668-01A1 |
| Project ID | NIH-11050763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have recently undergone solid organ transplantation and are at risk for multi-drug resistant infections.
✕Less likely to help
Patients who have not undergone solid organ transplantation or those without risk factors for MDRO infections may not benefit from this research.
What this research studies
This research investigates the role of gut bacteria in the risk of multi-drug resistant organism (MDRO) infections in patients who have received solid organ transplants. By analyzing the gut microbiome, the study aims to identify specific microbial biomarkers that can predict which patients are at higher risk for these infections. The goal is to develop better strategies for managing antibiotic use and to explore non-antibiotic therapies to reduce MDRO colonization. This approach could help improve patient outcomes by targeting those who need treatment while minimizing unnecessary antibiotic exposure.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for infections in organ transplant recipients, ultimately enhancing their recovery and survival rates.
How similar studies have gone: Previous research has shown promising results in using gut microbiome analysis to predict infection risks, indicating that this approach may be effective.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Uhlemann, Anne-Catrin — Columbia University Health Sciences
- Study coordinator: Uhlemann, Anne-Catrin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.