Identifying gut bacteria linked to drug-resistant infections after organ transplants
Microbial biomarkers of intestinal MDR colonization after solid organ transplantation
This study is looking at how the bacteria in your gut might affect the chances of getting tough infections after a solid organ transplant, with the hope of finding ways to better manage antibiotics and improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11050763 on NIH RePORTER |
What this research studies
This research investigates the role of gut bacteria in the risk of multi-drug resistant organism (MDRO) infections in patients who have received solid organ transplants. By analyzing the gut microbiome, the study aims to identify specific microbial biomarkers that can predict which patients are at higher risk for these infections. The goal is to develop better strategies for managing antibiotic use and to explore non-antibiotic therapies to reduce MDRO colonization. This approach could help improve patient outcomes by targeting those who need treatment while minimizing unnecessary antibiotic exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have recently undergone solid organ transplantation and are at risk for multi-drug resistant infections.
Not a fit: Patients who have not undergone solid organ transplantation or those without risk factors for MDRO infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for infections in organ transplant recipients, ultimately enhancing their recovery and survival rates.
How similar studies have performed: Previous research has shown promising results in using gut microbiome analysis to predict infection risks, indicating that this approach may be effective.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Uhlemann, Anne-Catrin — Columbia University Health Sciences
- Study coordinator: Uhlemann, Anne-Catrin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.