Identifying genetic variations linked to Alzheimer's disease
Copy Number Variation Identification and Association Study on Alzheimer's Disease Whole Genome Sequencing Data
This study is looking at how certain genetic changes might affect the risk of developing Alzheimer's disease, with the hope that understanding these changes can help create better treatments tailored just for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10884085 on NIH RePORTER |
What this research studies
This research investigates the genetic factors associated with Alzheimer's disease by analyzing whole genome sequencing data to identify copy number variations (CNVs). The study aims to understand how these genetic variations contribute to the risk and development of Alzheimer's, which could lead to better-targeted treatments. By examining both common and rare CNVs, the research seeks to uncover new insights into the disease's mechanisms and potential therapeutic targets. Patients may benefit from this research as it could pave the way for more personalized approaches to prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Alzheimer's disease, potentially resulting in better prevention strategies and targeted therapies.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lee, Wan-Ping — University of Pennsylvania
- Study coordinator: Lee, Wan-Ping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.