Identifying genetic variations in human tissues
Molecular and Computational Tools for Identifying Somatic Mosaicism in Human Tissues
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10827996
This study is looking at how tiny genetic changes that happen in our bodies after we're born can affect our health, especially in diseases like cancer, and it aims to help patients understand their own unique genetic makeup better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10827996 on ClinicalTrials.gov |
What this research studies
This research investigates the presence of somatic mosaicism, which refers to genetic variations that occur within an individual after conception. By utilizing advanced molecular and computational tools, the study aims to identify these variations across different human tissues, particularly focusing on their implications in diseases like cancer. The approach involves analyzing genomic sequences to uncover variations that may not be detectable with standard methods, thereby enhancing our understanding of how these changes contribute to health and disease. Patients may benefit from insights gained about their own genetic variations and how these may influence their health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of cancer or other diseases where somatic mutations may play a role.
Not a fit: Patients without any genetic predisposition to diseases related to somatic mosaicism may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for conditions associated with somatic mosaicism, particularly cancers.
How similar studies have performed: Previous research has shown promising results in identifying somatic mutations in various tissues, indicating that this approach has potential for significant advancements in understanding genetic variations.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLS, RYAN E — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: MILLS, RYAN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer