Identifying genetic variants that cause colon-related diseases
Zhao - Proj 2
This study is looking at how certain genes might play a role in colon diseases by examining tiny cells and their genetic information, with the goal of finding new ways to understand and treat these conditions for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10852731 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variants contribute to the development of colon-related diseases by analyzing multi-omics data, particularly from single-cell studies. The project aims to establish a framework for collecting and analyzing genomic data, using organoids to understand the functional effects of these variants. By collaborating with specialized cores for sequencing and data analysis, the research seeks to pinpoint disease-causal variants that could lead to better understanding and treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of colon-related diseases or those diagnosed with such conditions.
Not a fit: Patients without any genetic predisposition to colon-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and targeted therapies for patients with colon-related diseases.
How similar studies have performed: Other research has shown success in using multi-omics approaches to identify genetic variants associated with various diseases, indicating a promising avenue for this project.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Zhao, Siming — Dartmouth College
- Study coordinator: Zhao, Siming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.