Identifying genetic variants linked to neuropsychiatric diseases
High-throughput identification of causal variants underlying neuropsychiatric disease-related GWAS hits
This study is looking at how certain genes might affect brain health and contribute to conditions like bipolar disorder, using a special method to see how these genes work in the body, which could help us find better treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10766794 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to neuropsychiatric diseases by focusing on non-coding regions of the genome that may affect gene expression in the brain. Using a method called CRE-seq, researchers will analyze how specific genetic variants influence the binding of transcription factors, which are crucial for regulating gene activity. By creating a library of genetic constructs and measuring their effects in living tissue, the study aims to uncover the underlying mechanisms of these diseases. This approach could lead to a better understanding of conditions like bipolar disorder and inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with neuropsychiatric conditions such as bipolar disorder or those with a family history of these diseases.
Not a fit: Patients with neuropsychiatric disorders that are not linked to genetic factors or those who do not have a clear genetic component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of neuropsychiatric diseases, potentially improving diagnosis and treatment options for patients.
How similar studies have performed: Previous research using similar genomic approaches has shown promise in identifying genetic variants associated with various diseases, suggesting that this method could be effective in the context of neuropsychiatric disorders as well.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Corbo, Joseph — Washington University
- Study coordinator: Corbo, Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.