Identifying genetic variants linked to ion channel diseases
Official title: High-throughput discovery of disease-associated ion channel variants
Funded at Vanderbilt University Medical Center · NIH-11075277 · Data updated 2026-11-12
This study is looking at how certain genetic changes in ion channel genes might cause different health issues, and it's for anyone interested in understanding how these mutations can affect their health and help doctors make better diagnoses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $437,500 |
| NIH project number | 5R35GM150465-03 |
| Project ID | NIH-11075277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with known or suspected channelopathy disorders, particularly those with unexplained symptoms related to ion channel dysfunction, would be ideal candidates.
✕Less likely to help
Patients with diseases not related to ion channel dysfunction or those without genetic mutations may not benefit from this research.
What this research studies
This research investigates how specific genetic mutations in ion channel genes contribute to various diseases. By analyzing large datasets from biobanks that include genetic and health information, the team aims to identify which mutations are harmful and associated with specific health conditions. They will also use advanced techniques to study the effects of these mutations on ion channel function, focusing on key genes that impact multiple organ systems. This work could enhance our understanding of genetic disorders related to ion channels and improve diagnostic accuracy.
Why it matters
Potential benefit: If successful, this research could lead to better identification of genetic causes of diseases, allowing for more accurate diagnoses and targeted treatments.
How similar studies have gone: Previous research has successfully identified disease-associated genetic variants in other contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Glazer, Andrew M. — Vanderbilt University Medical Center
- Study coordinator: Glazer, Andrew M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.