Identifying genetic targets of natural selection in human genomes
Novel population-genetic methods for localizing targets of natural selection in diverse human genomes
['FUNDING_OTHER'] · BROWN UNIVERSITY · NIH-10993149
This study looks at how our genes have changed over time by comparing the DNA of different groups of people, helping us understand how these changes might affect health and traits, which could lead to better medical care in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10993149 on ClinicalTrials.gov |
What this research studies
This research investigates how human genomes have adapted over time by analyzing genetic variations across diverse populations. It employs advanced computational and statistical methods to identify mutations that may contribute to adaptation and disease. By examining whole genomes, the research aims to uncover the genetic basis of traits and disorders, providing insights into how different ancestries influence genetic architecture. The findings could enhance our understanding of human evolution and inform future medical approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from diverse ancestral backgrounds who may have genetic variations linked to specific traits or diseases.
Not a fit: Patients with no genetic variations or those from homogeneous ancestral backgrounds may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of genetic factors associated with diseases and adaptations, ultimately benefiting personalized medicine.
How similar studies have performed: Other research has successfully utilized similar computational methods to analyze genetic data, indicating a promising approach for this study.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAMACHANDRAN, SOHINI — BROWN UNIVERSITY
- Study coordinator: RAMACHANDRAN, SOHINI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.