Identifying genetic mutations that increase lung cancer risk
Discovery and characterization of clinically actionable germline mutations in DNA damage repair (DDR) pathway genes in lung cancer
['FUNDING_R37'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11081648
This study is looking at how certain inherited genetic changes might make some people more likely to get lung cancer, even if they don’t smoke, so we can find better ways to spot those at risk and help with early detection.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11081648 on ClinicalTrials.gov |
What this research studies
This research investigates the role of inherited genetic mutations in DNA damage repair (DDR) genes that may contribute to lung cancer susceptibility. By utilizing advanced next-generation sequencing technologies, the study aims to identify and characterize clinically actionable germline mutations in patients with lung cancer. The goal is to improve strategies for identifying high-risk individuals, particularly those who may not have traditional risk factors like smoking. This could lead to better surveillance and early detection methods for lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of lung cancer or those diagnosed with lung cancer, particularly non-smokers.
Not a fit: Patients with lung cancer who do not have any family history or genetic predisposition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of individuals at high risk for lung cancer, enabling earlier interventions and potentially saving lives.
How similar studies have performed: Other research has shown success in identifying genetic mutations related to cancer susceptibility, indicating that this approach has potential for meaningful advancements.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUKHERJEE, SEMANTI — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: MUKHERJEE, SEMANTI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.