Identifying genetic mutations in childhood cancers for better treatment
Genomic Expert Curation Panels for Pediatric Malignancies
This study is working to gather and understand the genetic changes linked to pediatric cancers like acute lymphoblastic leukemia, so doctors can make better treatment choices for kids facing these challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10894229 on NIH RePORTER |
What this research studies
This research focuses on creating expert panels to curate and analyze genetic mutations associated with pediatric cancers, particularly acute lymphoblastic leukemia. By addressing the current gaps in public databases regarding childhood cancer mutations, the project aims to improve the understanding of how these genetic variations impact diagnosis and treatment. The approach involves systematic cataloging of both common and rare mutations, collaborating with various organizations to enhance the clinical application of this knowledge. Ultimately, this research seeks to provide better insights into the genetic profiles of childhood tumors to inform treatment decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with acute lymphoblastic leukemia or other pediatric malignancies.
Not a fit: Patients with adult cancers or those outside the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for children with cancer based on their unique genetic profiles.
How similar studies have performed: Previous research has shown success in similar approaches to genetic curation in adult cancers, indicating potential for impactful outcomes in pediatric cases as well.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Griffith, Obi L. — Washington University
- Study coordinator: Griffith, Obi L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.