Identifying genetic markers that differentiate aggressive from less aggressive prostate cancer
Official title: Polymorphic L1 transposons as a Genetic Variable Distinguishing Aggressive from Indolent Prostate Cancer
Funded at Southeast Louisiana Veterans Health Care · NIH-10976406 · Data updated 2026-11-12
This study is looking for specific genetic markers in prostate cancer patients that can help doctors spot those who might develop more serious forms of the disease, so they can start treatment earlier and improve outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southeast Louisiana Veterans Health Care NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 30, 2022 |
| Project end | December 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005633-03 |
| Project ID | NIH-10976406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are prostate cancer patients who are at risk of developing metastatic disease.
✕Less likely to help
Patients with indolent prostate cancer who are not at risk of progression may not benefit from this research.
What this research studies
This research aims to discover biomarkers that can identify prostate cancer patients at high risk of developing aggressive metastatic disease. By analyzing the genomes of prostate cancer patients, the study focuses on polymorphic L1 retrotransposons (pL1s) as potential indicators of disease progression. The researchers have developed a novel method for detecting these genetic markers, which could enable earlier and more effective treatment for patients at risk. The goal is to provide clinicians with tools to intervene before the cancer becomes more severe.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and treatment of aggressive prostate cancer, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in identifying genetic markers for cancer progression, suggesting that this approach could be effective.
Where this research is happening
-
Southeast Louisiana Veterans Health Care
New Orleans, United States Active
Researchers
- Principal investigator: Belancio, Victoria Perepelitsa — Southeast Louisiana Veterans Health Care
- Study coordinator: Belancio, Victoria Perepelitsa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.