Identifying genetic factors that predict tuberculosis in close contacts of infected individuals
Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts
This study is looking at how your genes and immune system might help predict if someone who has been around tuberculosis (TB) patients will develop active TB, and it’s for people in Brazil who have been in close contact with TB.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10625312 on NIH RePORTER |
What this research studies
This research investigates how certain genetic factors and immune responses can predict the progression from asymptomatic tuberculosis (TB) to active TB disease in individuals who have been in close contact with TB patients. By analyzing blood samples and genetic data from participants in Brazil, the study aims to uncover the biological markers that indicate a higher risk of developing TB. The research will focus on understanding the role of specific genes and immune responses in the context of TB exposure, providing insights that could lead to better prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been in close contact with someone diagnosed with tuberculosis, particularly in Brazil.
Not a fit: Patients who are not in close contact with TB-infected individuals or those already diagnosed with active TB may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying individuals at high risk for developing active TB, allowing for timely intervention and treatment.
How similar studies have performed: Previous studies have shown promise in identifying genetic markers associated with TB risk, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Sterling, Timothy R — Vanderbilt University Medical Center
- Study coordinator: Sterling, Timothy R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.