Identifying genetic factors that lead to blood clots traveling to the lungs in patients with deep vein thrombosis.
Official title: Genetic Discovery and Functional Validation to Identify Precursors of Clot Embolization in those with a Deep Vein Thrombosis
Funded at University of Washington · NIH-10807021 · Data updated 2026-11-12
This study is looking at how certain genes might affect the risk of blood clots traveling from your legs to your lungs, which can be really serious, and it's for people who have had deep vein thrombosis (DVT) to help find out who might be at higher risk for these complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 1, 2021 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $625,301 |
| NIH project number | 5R01HL147894-04 |
| Project ID | NIH-10807021 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with deep vein thrombosis who may be at risk for pulmonary embolism.
✕Less likely to help
Patients who do not have deep vein thrombosis or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the genetic variations that may contribute to the risk of blood clots, specifically how they can travel from the deep veins to the lungs, causing serious complications like pulmonary embolism. By analyzing genetic data from patients with deep vein thrombosis (DVT), the study aims to uncover new genetic markers that could predict which patients are at higher risk for these dangerous events. The approach includes both genetic discovery and functional validation to understand the biological mechanisms involved. Patients may be asked to provide genetic samples and health information to help identify these risk factors.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and personalized treatment strategies for patients with deep vein thrombosis.
How similar studies have gone: Previous research has identified genetic factors related to blood clotting, suggesting that this approach has potential for success in uncovering new risk markers.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Smith, Nicholas L — University of Washington
- Study coordinator: Smith, Nicholas L
Related research
Other NIH-funded projects on the same topics.
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Understanding how DVT forms and heals to prevent vein scarring
This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.
-
Oscillatory blood flow and vein valve health to prevent clots
Aimed at understanding how the natural rhythmic blood flow in leg veins protects against clots and whether restoring that flow can prevent dangerous vein clots in hospitalized patients.
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Local anti-inflammatory therapy to help dissolve clots and prevent vein damage in DVT
Aims to test a local anti-inflammatory treatment to help resolve deep vein clots and reduce long-term vein problems in people with DVT.
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Neutrophil integrin α9 and blood clots after stroke in aging
This project looks at how a molecule on white blood cells called neutrophil integrin α9 might cause dangerous vein clots after a stroke, especially in older adults.
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Metabolic tricks to prevent and heal dangerous blood clots in the leg
A study at a university aims to see if shifting how certain blood cells use energy can stop leg clots from forming and help bodies clear clots faster, reducing future complications.
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Stopping long-term leg damage after deep vein clots by giving anti-inflammatory medicine around the vein
This will try giving anti-inflammatory medicine around the affected vein to lower the chance of long-term swelling, pain, and skin problems after a deep vein clot (DVT).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.