Identifying genetic factors that influence immune cell activity in Alzheimer's disease
Discovery and validation of genetic variants affecting microglial activation in Alzheimer's disease
This study is looking at how our genes might influence brain immune cells and their activity in people with Alzheimer's disease, with the hope of finding new treatments to help prevent memory loss and dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10758001 on NIH RePORTER |
What this research studies
This research investigates how genetic variations affect the activation of microglia, the immune cells in the brain, in relation to Alzheimer's disease. By analyzing genetic data and measuring microglial activation in both human brain tissue and living patients, the study aims to uncover the genetic basis for increased susceptibility to Alzheimer's. The goal is to develop targeted immune-based therapies that could help prevent cognitive decline and the progression to dementia. This comprehensive approach combines genetic analysis with advanced imaging techniques to better understand the role of microglia in Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 21 and older who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target immune responses in Alzheimer's disease, potentially slowing down or preventing cognitive decline.
How similar studies have performed: Previous research has shown promise in understanding the genetic factors influencing microglial activation, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: De Jager, Philip L — Columbia University Health Sciences
- Study coordinator: De Jager, Philip L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.