Identifying genetic factors that influence compulsive oxycodone use in rats
Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsive Oxycodone Intake in Outbred Rats
This study is looking at how genes and biology might make some rats more likely to become addicted to oxycodone, which could help us understand addiction better and find new ways to help people who struggle with it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11042769 on NIH RePORTER |
What this research studies
This research investigates the genetic and biological factors that contribute to addiction-like behaviors, specifically focusing on compulsive oxycodone intake in outbred rats. By utilizing next-generation sequencing and advanced animal models, the study aims to identify gene variants associated with increased vulnerability to substance use disorders. The research also includes the creation of a biobank to support further studies on the biological changes related to addiction. This comprehensive approach allows for a deeper understanding of the genetic underpinnings of addiction and pain response.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals with a history of opioid use disorder or those at risk for developing addiction.
Not a fit: Patients who do not have a history of substance use or are not at risk for addiction may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals struggling with addiction to opioids.
How similar studies have performed: Other research has shown success in identifying genetic factors related to addiction, suggesting that this approach has potential for meaningful discoveries.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: George, Olivier — University of California, San Diego
- Study coordinator: George, Olivier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.