Identifying genetic factors that influence chronic pain after surgery
Genetic Markers of Chronic Postsurgical Pain
This study is looking at how your genes might help predict if you'll experience long-lasting pain after surgery, and it's for anyone who is about to have an operation.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11057685 on NIH RePORTER |
What this research studies
This research investigates how genetic variations may predict the likelihood of developing chronic postsurgical pain (CPSP) in patients who undergo surgery. By analyzing a large cohort of over 3400 patients, the study aims to identify specific genetic markers associated with severe postoperative pain and the potential for chronic pain development. The approach includes genomic sequencing and self-reported pain assessments before and after surgery, allowing for a comprehensive understanding of the genetic factors involved. This could lead to more personalized pain management strategies tailored to individual genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals scheduled to undergo surgical procedures who are willing to participate in genetic testing and pain assessments.
Not a fit: Patients who are not undergoing surgery or those with pre-existing chronic pain conditions unrelated to surgical procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies that are customized based on a patient's genetic makeup, potentially reducing the incidence of chronic pain after surgery.
How similar studies have performed: Previous studies have shown promise in identifying genetic predictors of pain, but this research aims to utilize a larger and more diverse cohort, making it a significant advancement in the field.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Frangakis, Stephan — University of Michigan at Ann Arbor
- Study coordinator: Frangakis, Stephan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.