Identifying genetic factors that influence Alzheimer's disease risk
Defining high- and low-risk APOE õ4 haplotypes for AlzheimerâÂÂs disease
This study is looking at how different versions of a gene called APOE might affect your chances of getting Alzheimer's disease, so we can find better ways to prevent and treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Puget Sound Healthcare System NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11074522 on NIH RePORTER |
What this research studies
This research investigates the role of the apolipoprotein E gene (APOE) in Alzheimer's disease, focusing on how different genetic variations can affect an individual's risk of developing the condition. By analyzing genetic data from large studies, the researchers aim to uncover the mechanisms by which APOE contributes to Alzheimer's, which could lead to more targeted prevention and treatment strategies. The study will explore not only the well-known APOE ε4 allele but also other genetic variants in the surrounding region that may influence Alzheimer's risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those who are concerned about their genetic risk for developing the condition.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or those with early-onset forms of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating Alzheimer's disease based on individual genetic profiles.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- VA Puget Sound Healthcare System — Seattle, United States (Active)
Researchers
- Principal investigator: Yu, Chang-En — VA Puget Sound Healthcare System
- Study coordinator: Yu, Chang-En
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.