Identifying genetic factors that increase risk of DNA damage from chemicals
Chromatin regions, genes and pathways that confer susceptibility to chemical-induced DNA damage
This study is looking at how our genes might make some people more likely to get DNA damage from certain chemicals, like a harmful substance found in some air pollution, and it aims to help patients understand their own genetic risks so they can take better care of their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project ID | NIH-10559536 on NIH RePORTER |
What this research studies
This research investigates how certain genetic factors and chromatin regions make individuals more susceptible to DNA damage caused by environmental chemicals, specifically focusing on the carcinogen 1,3-butadiene. By studying both mouse models and human cell lines, the research aims to uncover the genetic and epigenetic interactions that lead to varying responses to chemical exposure. Patients may benefit from insights gained about their genetic predispositions to DNA damage, which could inform personalized prevention strategies. The research employs advanced techniques to analyze gene expression and chromatin structure in response to chemical exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those who have been exposed to environmental carcinogens.
Not a fit: Patients who have no history of exposure to chemical carcinogens or genetic predisposition to DNA damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic susceptibility to DNA damage, potentially guiding personalized treatment and prevention strategies for at-risk individuals.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to susceptibility to environmental toxins, making this approach promising.
Where this research is happening
College Station, UNITED STATES
- Texas A&m Agrilife Research — College Station, United States (Active)
Researchers
- Principal investigator: Rusyn, Ivan — Texas A&m Agrilife Research
- Study coordinator: Rusyn, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.