Identifying genetic factors that affect survival in acute myeloid leukemia
Penalized mixture cure models for identifying genomic features associated with outcome in acute myeloid leukemia
This study is looking at how certain genes might affect the health and recovery of people with acute myeloid leukemia (AML), with the goal of finding ways to create more personalized and effective treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10995349 on NIH RePORTER |
What this research studies
This research investigates how specific genetic features can influence outcomes for patients with acute myeloid leukemia (AML). By analyzing extensive genomic data from a large patient cohort, the study aims to identify molecular markers that could predict overall and disease-free survival. The approach utilizes advanced statistical models to handle complex data, allowing researchers to pinpoint which genetic variations are most relevant to patient outcomes. This could lead to better-targeted therapies and personalized treatment plans for AML patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia who are undergoing treatment or have completed treatment.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with any form of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prognostic tools and targeted therapies for patients with acute myeloid leukemia.
How similar studies have performed: Previous research using similar genomic analysis approaches has shown promise in identifying prognostic markers in various cancers, suggesting a potential for success in this study as well.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Archer, Kellie J. — Ohio State University
- Study coordinator: Archer, Kellie J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.