Identifying genetic factors that affect orofacial clefts in African populations
Refining the Genetic and Genomic Architecture of Non‐syndromic Orofacial Clefts
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-10788282
This study is looking at the genes that might affect how orofacial clefts, like cleft lip and palate, happen in families from African backgrounds, with the hope of finding better ways to prevent and treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10788282 on ClinicalTrials.gov |
What this research studies
This research aims to uncover genetic and genomic factors that influence the outcomes of orofacial clefts, particularly in families from African populations. By analyzing genetic data from individuals with cleft lip and palate, the researchers will identify specific genetic markers associated with these conditions. The study involves genotyping a large number of participants and conducting whole genome sequencing to better understand the genetic architecture of orofacial clefts. The findings could lead to improved prevention strategies and treatment options for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of orofacial clefts, particularly those from African populations.
Not a fit: Patients without orofacial clefts or those not from the targeted populations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for orofacial clefts, ultimately improving patient outcomes.
How similar studies have performed: Other research has shown success in identifying genetic factors related to orofacial clefts, making this approach promising.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUTALI, AZEEZ — UNIVERSITY OF IOWA
- Study coordinator: BUTALI, AZEEZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.