Identifying genetic factors that affect malaria transmission in children
Official title: Phenotype-based Screens to Identify Genetic Factors Associated with Gametocyte Development in Plasmodium falciparum
Funded at University of South Florida · NIH-11023562 · Data updated 2026-11-12
This study is looking at how certain genes affect the growth of malaria parasites in the blood of children in sub-Saharan Africa, with the hope of finding new ways to prevent the disease from spreading.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | November 12, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $700,288 |
| NIH project number | 1R01AI187153-01 |
| Project ID | NIH-11023562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children aged 0-11 years living in sub-Saharan Africa who are infected with Plasmodium falciparum.
✕Less likely to help
Patients outside the age range of 0-11 years or those not residing in sub-Saharan Africa may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence the development of malaria-causing parasites in the blood of infected individuals, particularly focusing on children in sub-Saharan Africa. By utilizing advanced genetic techniques, the study aims to identify specific genes that are crucial for the maturation of these parasites, which are necessary for transmission by mosquitoes. The approach includes creating a library of genetically modified parasites to observe how changes affect their development. This could lead to a better understanding of malaria transmission and potential new strategies for prevention.
Why it matters
Potential benefit: If successful, this research could lead to new methods for reducing malaria transmission, ultimately protecting children from this deadly disease.
How similar studies have gone: Previous research has shown success in identifying genetic factors in malaria parasites, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Adams, John H — University of South Florida
- Study coordinator: Adams, John H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.