Identifying genetic factors related to oxycodone dependence using mouse models.
A reduced Complexity Cross in BALB/c substrains to identify the genetic basis of oxycodone dependence phenotypes
['FUNDING_U01'] · NORTHEASTERN UNIVERSITY · NIH-11051452
This study is looking at how our genes might affect addiction to opioids like oxycodone, using mice to find new genetic clues that could help us understand why some people become dependent on these medications.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHEASTERN UNIVERSITY (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11051452 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic basis of opioid dependence, specifically focusing on oxycodone, by utilizing mouse models to uncover novel genetic factors and biological pathways. The study employs Reduced Complexity Crosses (RCCs) between BALB/c substrains to identify genetic variations that contribute to addiction traits. By analyzing brain tissue from these mice after controlled opioid dosing, researchers aim to validate functional genetic variants that may influence opioid dependence. This approach complements human genetic studies and seeks to provide insights into the heritable nature of substance use disorders.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals with a family history of opioid dependence or those who have experienced issues with opioid use.
Not a fit: Patients who do not have a genetic predisposition to substance use disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors involved in opioid dependence, potentially informing new treatment strategies for patients struggling with addiction.
How similar studies have performed: Other research has shown success in using genetic models to uncover factors related to addiction, making this approach promising yet still innovative.
Where this research is happening
BOSTON, UNITED STATES
- NORTHEASTERN UNIVERSITY — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRYANT, CAMRON D — NORTHEASTERN UNIVERSITY
- Study coordinator: BRYANT, CAMRON D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.