Identifying genetic factors related to Alzheimer's disease risk and protection
The Alzheimer Disease Sequence Analysis Collaborative
This study is looking for specific genes that might affect the chances of getting late-onset Alzheimer's disease, with the hope of finding better treatments for people who are at risk or already have the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10474474 on NIH RePORTER |
What this research studies
This research focuses on uncovering genetic variants that influence the risk of developing late-onset Alzheimer's disease. By utilizing advanced sequencing techniques, including whole exome and whole genome sequencing, the study analyzes a diverse group of participants to identify both protective and risk factors associated with the disease. The goal is to accelerate the development of targeted therapies that could improve treatment options for individuals at risk or affected by Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease, particularly those from diverse ethnic backgrounds, including Hispanic and African-American populations.
Not a fit: Patients with early-onset Alzheimer's disease or those without a genetic predisposition to late-onset Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that significantly improve treatment outcomes for patients with Alzheimer's disease.
How similar studies have performed: Previous research initiatives have successfully identified genetic factors related to Alzheimer's disease, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Haines, Jonathan L — Case Western Reserve University
- Study coordinator: Haines, Jonathan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.