Identifying genetic factors linked to Alzheimer's Disease
Genome-wide identification and characterization of Alzheimer's Disease-associated enhancers
This study is looking at how certain genes might affect the development of Alzheimer's Disease by examining special parts of our DNA, and it's designed for anyone interested in understanding more about the genetic factors that contribute to this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11045623 on NIH RePORTER |
What this research studies
This research investigates the genetic variants associated with Alzheimer's Disease by focusing on specific regulatory elements in the genome known as enhancers. Using advanced techniques, the team will analyze how these genetic variants influence the development and progression of Alzheimer's. The study employs induced pluripotent stem cells to create relevant brain cell types, allowing for a detailed examination of the genetic factors at play. By mapping these variants, the research aims to enhance our understanding of Alzheimer's and its underlying mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's Disease or those diagnosed with early-stage cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of Alzheimer's Disease, potentially paving the way for targeted therapies or preventive strategies.
How similar studies have performed: Previous research has successfully identified genetic variants linked to other diseases using similar genomic approaches, suggesting a promising avenue for Alzheimer's research.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Yu, Haiyuan — Cornell University
- Study coordinator: Yu, Haiyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.