Identifying genetic factors in Peyronie's and Dupuytren's diseases that lead to fibrosis and inflammation
Official title: Validation and Identification of Genetic Variants in Peyronie's and Dupuytren's Disease that Predispose to Fibrosis and Inflammation
Funded at University of Utah · NIH-11001535 · Data updated 2026-11-12
This study is looking at how certain genes might play a role in Peyronie's Disease and Dupuytren's Disease, which can cause physical changes and affect your daily life, with the hope of finding better treatments and helping those who are at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | February 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $496,505 |
| NIH project number | 5R01DK126903-04 |
| Project ID | NIH-11001535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with Peyronie's Disease or Dupuytren's Disease, particularly those with a family history of these conditions.
✕Less likely to help
Patients with other unrelated fibrotic conditions or those without a diagnosis of Peyronie's or Dupuytren's diseases may not benefit from this research.
What this research studies
This research investigates the genetic variants associated with Peyronie's Disease (PD) and Dupuytren's Disease (DD), which are conditions that cause physical deformities and can significantly impact quality of life. The study aims to understand how specific genes, such as NELL1, CTDSPL, and ZNF277, contribute to the development of fibrosis and inflammation in these diseases. By using laboratory assays and animal models, researchers will explore the molecular mechanisms behind these conditions, potentially leading to better treatment options. The findings could help identify individuals at risk and improve management strategies for those affected.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from Peyronie's and Dupuytren's diseases.
How similar studies have gone: Previous research has shown promise in understanding genetic contributions to similar fibrotic conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Pastuszak, Alexander Wojciech — University of Utah
- Study coordinator: Pastuszak, Alexander Wojciech
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.