Identifying genetic factors in Alzheimer's disease through tandem repeat analysis
Novel approaches to identify tandem repeat expansions in neurodegenerative disease
This study is looking at how certain genetic changes might play a role in Alzheimer's disease, using special techniques to find patterns that could help us understand why some people get the disease, and it's for anyone interested in the genetics behind Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11054682 on NIH RePORTER |
What this research studies
This research investigates the genetic underpinnings of Alzheimer's disease (AD) by focusing on tandem repeat expansions, which are often overlooked in traditional genetic studies. The team employs advanced long-read sequencing techniques to accurately assess these tandem repeats, which may contribute significantly to the risk of developing AD. By analyzing genetic samples, the researchers aim to identify specific repeat expansions that correlate with Alzheimer's, potentially leading to new insights into the disease's causes and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with a family history or genetic predisposition.
Not a fit: Patients with non-genetic forms of dementia or those without a family history of Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved genetic understanding and potential new targets for treatment in Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in identifying genetic factors in neurodegenerative diseases using similar genomic approaches, indicating potential for success in this novel investigation.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Valdmanis, Paul Nils — University of Washington
- Study coordinator: Valdmanis, Paul Nils
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.