Identifying genetic factors in aggressive breast cancer using a new mouse model
Determining susceptibility loci in triple negative breast cancer using a novel pre-clinical model
This study is looking at how different genes affect the behavior of triple negative breast cancer and how well treatments work, using a special mouse model to help us understand this type of cancer better and find better ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11049056 on NIH RePORTER |
What this research studies
This research investigates how genetic variations influence the behavior of triple negative breast cancer (TNBC) and the effectiveness of treatments. By developing a novel mouse model that incorporates diverse genetic backgrounds, the study aims to better understand the mechanisms behind TNBC aggression and treatment responses. This approach allows for a more accurate representation of human disease, potentially leading to improved therapeutic strategies. The research utilizes advanced genetic techniques to analyze how different genetic factors contribute to tumor development and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple negative breast cancer, particularly those with a family history of the disease or known genetic predispositions.
Not a fit: Patients with non-triple negative breast cancer or those without a genetic component to their cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with triple negative breast cancer.
How similar studies have performed: Other research has shown promise in using genetically diverse models to better understand cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Makowski-Hayes, Liza — University of Tennessee Health Sci Ctr
- Study coordinator: Makowski-Hayes, Liza
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.