Identifying genetic factors and symptoms of Lyme neuroborreliosis using mouse models
Official title: Exploring the Collaborative Cross resource to identify different phenotypes of Lyme neuroborreliosis and disease-contributing genetic factors
Funded at Michigan State University · NIH-11139771 · Data updated 2026-11-12
This study is creating a special mouse model to help us understand how Lyme disease can affect the nervous system, which could lead to better treatments for people dealing with Lyme neuroborreliosis.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $177,351 |
| NIH project number | 7R21AI168904-02 |
| Project ID | NIH-11139771 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced Lyme disease and are showing neurological symptoms.
✕Less likely to help
Patients who have not been diagnosed with Lyme disease or do not exhibit neurological symptoms may not benefit from this research.
What this research studies
This research aims to develop a mouse model that accurately represents Lyme neuroborreliosis (LNB), a serious complication of Lyme disease. By utilizing the Collaborative Cross resource, the study will explore how different genetic backgrounds in mice can influence the development of neurological symptoms associated with LNB. The researchers will focus on understanding how the bacteria responsible for Lyme disease can invade the central and peripheral nervous systems, leading to various neurological issues. This work is crucial for improving our understanding of the disease and potentially guiding future treatments.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for patients suffering from Lyme neuroborreliosis.
How similar studies have gone: While there have been studies on Lyme disease, the specific approach of using the Collaborative Cross resource to develop a mouse model for LNB is relatively novel.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Rogovsky, Artem S — Michigan State University
- Study coordinator: Rogovsky, Artem S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.