Identifying genetic factors affecting brain development and disorders
1/2 Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
This study is looking at how certain genetic differences affect how genes work in the brain as it develops, which could help us understand conditions like autism and Alzheimer's disease better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11012376 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variations, known as expression quantitative trait loci (eQTLs), influence gene expression in different cell types during human brain development. By analyzing brain tissue samples from various developmental stages, the researchers aim to uncover the relationship between these genetic factors and neurodevelopmental disorders. The study employs advanced techniques such as whole-genome sequencing and RNA sequencing to gather detailed information about gene expression patterns. This could help in understanding the biological basis of conditions like autism and Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodevelopmental disorders such as autism or Alzheimer's disease, as well as healthy participants across various developmental stages.
Not a fit: Patients with conditions unrelated to neurodevelopmental or neuropsychiatric disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of neurodevelopmental disorders, potentially guiding future treatments and interventions.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to brain development and disorders, indicating that this approach is promising and builds on established findings.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sestan, Nenad — Yale University
- Study coordinator: Sestan, Nenad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.