Identifying genetic changes that increase the risk of oral cancer from premalignant lesions
Genetic Alterations That Confer High Risk to Oral Premalignant Lesions
This study is looking at how certain genetic changes can make it more likely for early signs of mouth cancer to turn into full-blown cancer, especially in people who have been exposed to tobacco, and it hopes to find new ways to help those at high risk stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10861000 on NIH RePORTER |
What this research studies
This research investigates the genetic alterations that increase the risk of oral premalignant lesions progressing to oral squamous cell carcinoma (OSCC). By studying mouse models exposed to tobacco-related carcinogens, the team aims to understand how mutations in key genes like TP53 and CDKN2A affect the immune environment and the likelihood of cancer development. The findings could lead to new preventive strategies for patients with high-risk oral lesions, potentially improving their outcomes. The research focuses on the biological mechanisms behind these genetic changes and their impact on treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with high-risk oral premalignant lesions.
Not a fit: Patients with low-risk oral lesions or those without any premalignant conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective preventive strategies that reduce the progression of premalignant lesions to oral cancer.
How similar studies have performed: Previous research has shown that targeting genetic alterations in cancer can lead to breakthroughs in treatment, suggesting this approach has potential for success.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Caulin, Carlos — University of Arizona
- Study coordinator: Caulin, Carlos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.