Identifying genetic changes in saliva and tissue to predict oral cancer risk
Somatic Mutations in Tissue and Saliva as Prognostic and Screening Biomarkers for Oral Premalignancy
This study is looking to help people at risk of oral cancer by finding specific genetic changes in tissue and saliva samples, which could help doctors tell the difference between harmless conditions and those that might lead to cancer, making it easier to monitor and treat patients early on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10833514 on NIH RePORTER |
What this research studies
This research aims to improve the screening and prognostication of oral cavity squamous cell carcinoma (OCSCC) by identifying specific genetic mutations in premalignant lesions. By analyzing both tissue biopsies and saliva samples, the study seeks to differentiate between benign inflammatory conditions and high-risk dysplastic lesions. The approach involves a retrospective case-cohort study to validate mutations found in tissue samples and a longitudinal study using saliva to detect mutations before cancer diagnosis. This could lead to more effective monitoring and treatment strategies for patients at risk of developing oral cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with premalignant oral lesions or those at high risk for developing oral cancer.
Not a fit: Patients with no history of oral lesions or those who have already been diagnosed with advanced oral cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a reliable method for early detection of oral cancer, allowing for timely intervention and improved patient outcomes.
How similar studies have performed: Previous research has shown promise in using genetic mutations as biomarkers for cancer detection, indicating that this approach may be effective.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Agrawal, Nishant — University of Chicago
- Study coordinator: Agrawal, Nishant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.