Identifying genetic changes from environmental factors to prevent cancer in healthy people
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
This study is looking at how things in our environment and our daily habits can cause changes in our DNA that might lead to cancer, and it’s for anyone interested in understanding their own cancer risks better so they can take steps to stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10976436 on NIH RePORTER |
What this research studies
This research investigates how environmental exposures and lifestyle choices lead to specific genetic mutations in healthy individuals. By analyzing DNA samples, the study aims to identify unique mutational signatures that indicate potential cancer risks. The approach utilizes advanced computational tools to detect these signatures and understand the mutational processes at play. The ultimate goal is to develop personalized strategies for cancer prevention based on an individual's mutational profile.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy individuals who may be at risk of cancer due to environmental exposures or lifestyle factors.
Not a fit: Patients who are already diagnosed with cancer or have a significant genetic predisposition to cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized cancer prevention strategies that help individuals avoid developing cancer.
How similar studies have performed: Previous research has successfully identified mutational signatures in cancer patients, suggesting that this approach could be effective for healthy individuals as well.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Alexandrov, Ludmil B — University of California, San Diego
- Study coordinator: Alexandrov, Ludmil B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.