Identifying genetic causes of infertility using advanced cell models
Official title: Project II
Funded at Magee-Women's Res Inst and Foundation · NIH-10992992 · Data updated 2026-11-12
This study is exploring new ways to understand infertility by creating lab models that mimic how reproductive cells develop, helping to find hidden genetic factors that might be causing problems for people trying to conceive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | September 1, 2019 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $302,591 |
| NIH project number | 2P50HD096723-06 |
| Project ID | NIH-10992992 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing unexplained infertility or those diagnosed with non-obstructive azoospermia.
✕Less likely to help
Patients with infertility due to purely anatomical issues or those who do not have a genetic component to their infertility may not benefit from this research.
What this research studies
This research focuses on understanding infertility by creating advanced in vitro models that mimic the development of reproductive cells. By using these models, researchers aim to identify genetic and epigenetic factors that contribute to infertility, particularly in cases where traditional genetic testing has been inconclusive. The project employs innovative techniques, including the use of mouse embryonic stem cells and human induced pluripotent stem cells, to screen for genetic variants that may cause infertility. This approach aims to enhance the accuracy and speed of diagnosing infertility-related genetic issues, ultimately leading to better treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for individuals facing infertility.
How similar studies have gone: Previous research has shown promise in using in vitro models to study genetic factors in infertility, indicating that this approach has potential for success.
Where this research is happening
-
Magee-Women's Res Inst and Foundation
Pittsburgh, United States Active
Researchers
- Principal investigator: Schimenti, John C — Magee-Women's Res Inst and Foundation
- Study coordinator: Schimenti, John C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.