Identifying genetic causes of chronic respiratory diseases
Official title: Use of Tiered Genetic Sequencing and Specialty Referral for Identifying and Managing Rare Genetic Causes of Chronic Suppurative Respiratory Disease
Funded at Univ of North Carolina Chapel Hill · NIH-11011339 · Data updated 2026-11-12
This study is looking to help people with ongoing respiratory issues, like frequent sinus infections and bronchitis, by using genetic testing to find out if there are any genetic reasons behind their conditions, which could lead to better ways to manage and prevent these problems.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | January 15, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $363,360 |
| NIH project number | 5U01HL172658-02 |
| Project ID | NIH-11011339 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals, both children and adults, who experience chronic respiratory issues and may have underlying genetic conditions.
✕Less likely to help
Patients with chronic respiratory diseases that are not linked to genetic factors may not benefit from this research.
What this research studies
This research focuses on understanding chronic suppurative respiratory diseases, which include conditions like recurrent sinusitis and bronchitis. By using tiered genetic sequencing and specialty referrals, the project aims to accurately diagnose genetic conditions that contribute to these diseases. Patients will undergo clinical evaluations and genetic testing to identify underlying genetic causes, which can lead to more effective management and prevention strategies. The research builds on previous studies to enhance the understanding of genetic disorders related to respiratory health.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and management of chronic respiratory diseases, ultimately enhancing patient quality of life.
How similar studies have gone: Previous studies have successfully identified genetic causes of respiratory diseases, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Olivier, Kenneth N. — Univ of North Carolina Chapel Hill
- Study coordinator: Olivier, Kenneth N.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.