Identifying genetic and environmental factors influencing substance use in children
Using transmitted and untransmitted gene networks to identify molecular pathways to substance use & misuse in genetically controlled twins
This study looks at how both genes and the home environment influence kids' use of substances like alcohol, nicotine, and cannabis, especially by comparing twins to see how their backgrounds and inherited traits play a role in these behaviors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10886086 on NIH RePORTER |
What this research studies
This research investigates how genetic and environmental factors contribute to substance use and misuse in children, particularly focusing on alcohol, nicotine, and cannabis. By studying genetically controlled twins, the research aims to uncover the complex interactions between inherited genetic risks and the home environments created by parents. The methodology includes advanced genetic analysis techniques to measure the impact of both transmitted and untransmitted parental genes on children's substance use behaviors. This approach seeks to provide a clearer understanding of the pathways leading to substance use disorders in youth.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who may be at risk for substance use due to genetic or environmental factors.
Not a fit: Patients who are older than 11 years or those without a family history of substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and interventions for substance use disorders in children.
How similar studies have performed: Previous research has shown success in using genetic and environmental factors to understand substance use, making this approach both relevant and promising.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Gillespie, Nathan Alexander — Virginia Commonwealth University
- Study coordinator: Gillespie, Nathan Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.