Identifying genes that increase the risk of colorectal cancer
Transcriptome-wide association study to identify susceptibility genes for colorectal cancer
This study is looking at how our genes might affect the risk of colorectal cancer, using a new method to find out which genes could make someone more likely to develop the disease, so that patients can better understand their own genetic risk and improve prevention and treatment options.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10676904 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to colorectal cancer (CRC) risk by using a novel approach called transcriptome-wide association study (TWAS). It aims to identify susceptibility genes by analyzing gene expression data and genetic variants associated with CRC. The study will build predictive models of gene expression from various tissues and apply these models to existing genetic data to uncover new risk genes and understand the mechanisms behind them. Patients may benefit from insights into their genetic risk for CRC, which could inform prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of colorectal cancer or those who are at increased genetic risk for the disease.
Not a fit: Patients who do not have a genetic predisposition to colorectal cancer or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and identification of genetic risk factors for colorectal cancer, potentially improving screening and prevention strategies for patients.
How similar studies have performed: Previous research using transcriptome-wide association studies has shown promise in identifying genetic risk factors for various diseases, suggesting that this approach could be effective for colorectal cancer as well.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Guo, Xingyi — Vanderbilt University Medical Center
- Study coordinator: Guo, Xingyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.