Identifying genes that increase the risk of breast cancer
Integrating genomic and transcriptomic data to identify breast cancer susceptibility genes
This study is looking at how our genes might affect the risk of getting breast cancer, especially in people from different backgrounds, to help find better ways to prevent and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10892700 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to breast cancer risk by integrating genomic and transcriptomic data. It aims to identify specific genes associated with breast cancer susceptibility among diverse populations, including those of African, Asian, and European descent. The study will utilize RNA sequencing and high-density genotyping to create models that predict gene expression, which will then be analyzed in relation to breast cancer risk. By understanding these genetic links, the research seeks to improve disease prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include women of African, Asian, or European descent who are at risk for breast cancer or have a family history of the disease.
Not a fit: Patients who do not belong to the specified ethnic groups or who do not have a family history of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of individuals at high risk for breast cancer, enabling earlier interventions and personalized treatment options.
How similar studies have performed: Previous research has successfully identified genetic variants linked to breast cancer risk, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Zheng, Wei — Vanderbilt University Medical Center
- Study coordinator: Zheng, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.